Immune response measured in human volunteers vaccinated with autoclaved Leishmania major vaccine mixed with low dose of BCG
نویسندگان
چکیده
منابع مشابه
Evaluation of protectivity and immunogenicity of Alum precipitated autoclaved Leishmania major vaccine mixed with Mycobacterium Vaccae in the murine model of Leishmaniasis
.
متن کاملSafety and immunogenicity of an autoclaved Leishmania major vaccine.
OBJECTIVE To test the safety and immunogenicity of two doses of autoclaved L. major (ALM) vaccine mixed with BCG. SETTING Kala-azar endemic area of eastern Sudan. DESIGN This was a randomised, double blind and BCG controlled phase I/II study. SUBJECTS Eighty healthy volunteers (forty children and forty adults) with no past history of kala-azar, no reactivity to leishmanin antigen and with...
متن کاملEvaluation of immune response against autoclaved Leishmania major incorporated into positively charged liposomes in Balb/c mice
Background and aim: Efficacy of vaccines is mainly depending on the type of adjuvant used. Efficacy trials of first generation vaccine against leishmaniasis showed a limited efficacy due to lack of an appropriate adjuvant. The objective of this study was to investigate whether positively charged liposomes containing ALM could induce Th1 type immune response in susceptible Balb/c mice.Mate...
متن کاملمقایسه اثر واکسیناسیون BCG استنشاقی با تزریق زیرپوستی بر تولید نیتریک اکساید در ماکروفاژها و میزان نهفتگی انگل در بدن موش BALB/c آلوده به لیشمانیا ماژور
Objective: In this research, the effect of intranasal and subcutaneous BCG vaccination was compared on nitric oxide production by peritoneal macrophages and the load of parasite burden in liver and spleen of infected BALB/c mice. Materials & Methods: Twenty male 6-8 weeks old BALB/c mice were vaccinated with appropriate dose of BCG through intranasal and subcutaneous routs. They received au...
متن کاملDouble-Blind Randomized Efficacy Field Trial of Alum Precipitated Autoclaved Leishmania major (Alum-ALM) Vaccine Mixed With BCG Plus Imiquimod Vs. Placebo Control Group
BACKGROUND Canine visceral leishmaniasis (CVL) is not only an emerging veterinary concern but also a public health threat in endemic areas. The aim of this study was to assess the efficacy, immunogenicity and safety of two doses of aluminum hydroxide (alum) precipitated Leishmania major (Alum-ALM) mixed with BCG plus imiquimod against CVL. METHODS A total of 560 ownership dogs were serologica...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2003
ISSN: 0009-9104
DOI: 10.1046/j.1365-2249.2003.02299.x